EC Number   |
Protein Variants |
Reference |
|---|
   3.1.25.1 | A26Q |
not processive |
170714 |
| 3.1.25.1 | A3D |
AP-specific nicking possible, low level of dimer specific nicking |
170700 |
| 3.1.25.1 | A3E |
AP-specific nicking possible, low level of dimer specific nicking |
170700 |
| 3.1.25.1 | A3K |
substantial level of AP- and dimer specific nicking, not processive |
170700, 170714 |
| 3.1.25.1 | A3L |
substantial level of AP- and dimer specific nicking, not processive |
170700, 170714 |
| 3.1.25.1 | A3Q |
substantial level of AP- and dimer specific nicking, not processive |
170700, 170714 |
| 3.1.25.1 | D35A |
site-directed mutagenesis, the mutant shows no deoxyinosine cleavage activity |
-, 664112 |
| 3.1.25.1 | DELTAC127 |
C127-truncated, total loss of activity |
170703 |
| 3.1.25.1 | E23D |
active site mutant, retains full substrate binding ability but shows complex structure differences, crystal structure determination with a bound DNA duplex in comparison to the wild-type enzyme |
656844 |
| 3.1.25.1 | E23D |
no detectable N-glycosylase activity on pyrimidine dimers, partial retention of AP-lyase activity |
170714 |
