EC Number   |
Protein Variants |
Reference |
|---|
   2.7.7.56 | M6L |
exclusively localised to mitochondria |
693409 |
| 2.7.7.56 | more |
enzyme mutant deficient in tRNA nucleotidyltransferase and polynucleotide phosphorylase activity grows slowly at 37°C, shows a dramatically reduced tRNATyrsu3+ suppressor activity, displays reversible cold-sensitivity, and performs normal tRNA synthesis, ribosome structure and function are severely affected, particularly at lower temperatures of 31°C and below |
643527 |
| 2.7.7.56 | R127A |
mutation has no influence on the structure |
662322 |
| 2.7.7.56 | R68Q-R73Q-R76Q |
triple mutant RNase PH crystallize as a dimer, compared to wild-type enzyme that crystallizes as a hexamer |
663333 |
| 2.7.7.56 | R69S |
mutation has no influence on the structure |
662322 |
| 2.7.7.56 | R69S/R77S |
mutation leads to the dissociation of RNase PH hexamer into dimers without perturbing the overall monomeric structure |
662322 |
| 2.7.7.56 | R74S |
mutation leads to the dissociation of RNase PH hexamer into dimers without perturbing the overall monomeric structure |
662322 |
| 2.7.7.56 | R74S/R77S |
mutation leads to the dissociation of RNase PH hexamer into dimers without perturbing the overall monomeric structure |
662322 |
| 2.7.7.56 | R77S |
mutation has no influence on the structure |
662322 |
