EC Number   |
Protein Variants |
Reference |
|---|
   2.7.3.9 | C502A |
active site mutant |
-, 721630 |
| 2.7.3.9 | G338D |
significant loss of activity, no phosphorylation |
642530 |
| 2.7.3.9 | G338E |
significant loss of activity, no phosphorylation |
642530 |
| 2.7.3.9 | G338H |
significant loss of activity, diminishes phosphorylation |
642530 |
| 2.7.3.9 | G338N |
significant loss of activity |
642530 |
| 2.7.3.9 | G338R |
significant loss of activity, diminishes phosphorylation |
642530 |
| 2.7.3.9 | G338V |
significant loss of activity,decrease in phosphorylation |
642530 |
| 2.7.3.9 | G356S |
the mutant shows reduced dimerization affinity and lower autophosphorylation activity compared to the wild type enzyme |
761092 |
| 2.7.3.9 | H15D |
10-fold increase of Km, 1000-fold decrease of Vmax |
642528 |
| 2.7.3.9 | H186D |
the phosphomimetic mutant of the N-terminal domain of enzyme I shows reduced thermal stability compared to the wild type enzyme |
721436 |
