EC Number |
Protein Variants |
Reference |
---|
2.7.1.76 | D78A |
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity |
-, 640565 |
2.7.1.76 | D78E |
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity |
-, 640565 |
2.7.1.76 | D78N |
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity |
-, 640565 |
2.7.1.76 | D84A |
mutation in dGK of dAK/dGK, increase of dAK activity |
-, 641989 |
2.7.1.76 | D84E |
mutation in dGK of dAK/dGK, increase of dAK activity |
-, 641989 |
2.7.1.76 | D84N |
mutation in dGK of dAK/dGK, increase of dAK activity |
-, 641989 |
2.7.1.76 | R79k |
2 types of mutants, one bears the mutation on both the dAK and dGK subunits while the other, called R79K:dGK, has the mutation on the dGK subunit only, strong increase in dAK activity, activation of dAK by deoxyguanosine is nearly eliminated in the case of R79K:dGK, while for the tandem mutated R79K mutant a 30% inhibition is observed, inhibition by dATP is reduced |
-, 640565 |