EC Number   |
Protein Variants |
Reference |
|---|
   2.7.1.68 | D203A |
catalytically inactive. Expression in Xenopus laevis oocyte has no effect on epithelial sodium channel activity |
693018 |
| 2.7.1.68 | D214A |
the mutant displays a complete loss of activity |
-, 759179 |
| 2.7.1.68 | D227A |
catalytically inactive. Expression in Xenopus laevis oocyte has no effect on epithelial sodium channel activity |
693018 |
| 2.7.1.68 | D227A |
site-directed muatgenesis, inactive mutant |
662546 |
| 2.7.1.68 | D253A |
mutant lacking kinase activity. Overexpression compromises uropod formation and rear retraction during chemotaxis |
694079 |
| 2.7.1.68 | D266A |
site-directed mtagenesis, mutation of the putative ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate binding site, cells form extremely extended bipolar neurits even in presence of serum, failed to interfere with cell flattening and neurite extension |
660641 |
| 2.7.1.68 | D276A |
the mutant displays a complete loss of activity |
-, 759179 |
| 2.7.1.68 | D309N |
greatly reduced kinase activity towards 1-phosphatidyl-1D-myo-inositol 4-phosphate |
641847 |
| 2.7.1.68 | D309N |
inactive |
759168 |
| 2.7.1.68 | D309N |
inactive mutant |
722815 |
