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EC Number
Protein Variants
Commentary
Reference
2.5.1.57
M42L
mutant shows the additional 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity like the wild type enzyme
671868
2.5.1.57
M42T
the mutation abolishes the 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity completely without compromising the Neu5Ac-9-P synthase activity
671868
2.5.1.57
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by replacing the antifreeze-like domain of the human NeuNAc-9-P synthase with the mouse antifreeze-like domain, the chimeric protein retains almost half of the ability of the human enzyme for 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid-9-phosphate synthesis while the N-acetylneuraminate 9-phosphate production is reduced to less than 10%, the chimeric enzyme is less resistant to high temperatures compared to the wild type enzyme
685801
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