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EC Number Protein Variants Commentary Reference
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21C160A loss of catalytic efficiency by 79%. Renders the enzyme 5fold less efficient than wild-type. Displays no discernible growth defect in no-carbon essential (NCE) medium containing dicyanocobinamide and glycerol or ethanolamine relative to that of a strain that synthesizes wild-type 704323
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21G171D loss of catalytic efficiency by more than 99%, has less affinity for 5,6-dimethylbenzimidazole. Retains activity to support growth, but only when 5,6-dimethylbenzimidazole is present in the medium. Does not support the growth of strain JE2423 on ethanolamine in medium that contains dicyanocobinamide but lacks 5,6-dimethylbenzimidazole 704323
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21G171D/M325A requires cobalamin for growth regardless of the carbon source used 704323
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21G257A loss of catalytic efficiency by 64% 704323
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21G257D loss of catalytic efficiency by more than 99%, has less affinity for 5,6-dimethylbenzimidazole. Does not respond to 5,6-dimethylbenzimidazole and requires cobalamin to grow. Does not support the growth of strain JE2423 on ethanolamine in medium that contains dicyanocobinamide but lacks 5,6-dimethylbenzimidazole 704323
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21G257D/P12G is cobalamin auxotroph on glycerol or ethanolamine. P12G does not alter the effect of the G257D mutation 704323
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21G320D loss of catalytic efficiency by more than 99%, is unstable, retains activity to support growth, but only when 5,6-dimethylbenzimidazole is present in the medium. Does not support the growth of strain JE2423 on ethanolamine in medium that contains dicyanocobinamide but lacks 5,6-dimethylbenzimidazole 704323
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21H289A counteracts the effect of the G320D substitution 704323
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21I321S specific activity with p-cresol and 5,6-dimethylbenzimidazole decreased 721677
Show all pathways known for 2.4.2.21Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.21M325A grows in the absence of exogenous 5,6-dimethylbenzimidazole, albeit at a rate slower than that of a strain making wild-type. Addition of 5,6-dimethylbenzimidazole to the medium allows the strain making M325A to grow as fast as a strain making wild-type 704323
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