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EC Number
Protein Variants
Commentary
Reference
2.4.2.12
A244M
the mutation prevents inhibitor binding
735872
2.4.2.12
D219A
inactive
735872
,
759503
2.4.2.12
D219S
the mutation leads to a switch in substrate affinity
735872
2.4.2.12
D313A
inactive
759503
2.4.2.12
DELTA D93
naturally occuring mutation in CHS-828 or APO866 resistant cell lines, about 20% of wild type aczivity
721934
2.4.2.12
G217R
the mutation prevents inhibitor binding
735872
2.4.2.12
G384A
inactive
735872
2.4.2.12
H191R
activity reduced by about 50%
721934
2.4.2.12
H191R
the mutation prevents inhibitor binding
735872
2.4.2.12
H191R/K342R
naturally occuring mutation in APO866 resistant cell line
721934
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