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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221D242A site-directed mutagenessis, altered mutant temperature dependence and GDP-fucose/GDP dissociation constants compared to the wild-type, the mutant shows about 10% increased activity compared to the wild-type enzyme 723541
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221D244A site-directed mutagenessis, altered mutant temperature dependence and GDP-fucose/GDP dissociation constants compared to the wild-type, the mutant shows reduced activity compared to the wild-type enzyme 723541
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221D297A site-directed mutagenesis, the mutant shows 15% activity compared to the wild-type enzyme 722118
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221D309N site-directed mutagenessis, altered mutant temperature dependence and GDP-fucose/GDP dissociation constants compared to the wild-type, the mutant shows reduced activity compared to the wild-type enzyme 723541
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221E396A site-directed mutagenesis, the mutant shows 8% activity compared to the wild-type enzyme 722118
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221E54A site-directed mutagenesis, inactive mutant 722118
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221F199A site-directed mutagenessis, altered mutant temperature dependence and GDP-fucose/GDP dissociation constants compared to the wild-type, the mutant shows reduced activity compared to the wild-type enzyme 723541
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221F261A site-directed mutagenessis, altered mutant temperature dependence and GDP-fucose/GDP dissociation constants compared to the wild-type, the mutant shows reduced activity compared to the wild-type enzyme 723541
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221F357A site-directed mutagenessis, altered mutant temperature dependence and GDP-fucose/GDP dissociation constants compared to the wild-type, the mutant shows reduced activity compared to the wild-type enzyme 723541
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.221G19Q site-directed mutagenesis, the mutation affects both secretion and fucosylation 736861
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