EC Number   |
Protein Variants |
Reference |
|---|
   2.3.2.31 | A46P |
parkin disease mutant, loss of activity |
757731 |
| 2.3.2.31 | C357A |
the mutant shows wild type activity |
745880 |
| 2.3.2.31 | C361A |
mutation in isoform RFA4, affects its own ubiquitination and capability to ubiquitinate PYL4 |
758055 |
| 2.3.2.31 | C431F |
parkin disease mutant, loss of activity |
757731 |
| 2.3.2.31 | C431S/H433A |
RING2 mutant, able to trap the catalytic parkin-ubiquitin intermediate |
757792 |
| 2.3.2.31 | E321A/C431S/H433A |
UBR2 patch mutant of parkin. In contrast to C431S/H433A, this mutant is defective in ubiquitin charging even in the presence of phosphoubiquitin |
757792 |
| 2.3.2.31 | E352A |
moderate reduction of ubiquitination activity |
756593 |
| 2.3.2.31 | G430D |
parkin disease mutant, loss of activity |
757731 |
| 2.3.2.31 | H302A/E321A/C431S/H433A |
60fold reduced in ubiquitin charging of the RING2 |
757792 |
| 2.3.2.31 | H359A |
catalytic loop mutant |
746509 |
