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Results 1 - 10 of 14 > >>
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25G197A site-directed mutagenesis, the mutant enzyme shows altered activity compared to the wild-type enzyme producing heptaketides 722089
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25G197T site-directed mutagenesis, the mutant enzyme shows altered activity compared to the wild-type enzyme producing hexaketides 722089
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25G197W site-directed mutagenesis, the mutant enzyme shows altered activity compared to the wild-type enzyme producing tri- and pentaketides 722089
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25G207A site-directed mutagenesis, the G207A mutant loses the octaketide-forming activity and yields the heptaketide aloesone in addition to 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one/2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one 722034
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25G207F site-directed mutagenesis, the bulky substitution G207F mutant loses the octaketide-forming activity and yields the pentaketide 2,7-dihydroxy-5-methylchromone 722034
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25G207L site-directed mutagenesis, the bulky substitution G207F mutant loses the octaketide-forming activity and yields the pentaketide 2,7-dihydroxy-5-methylchromone 722034
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25G207M site-directed mutagenesis, OKS G207M mutant completely loses the octaketide-forming activity, but efficiently produces an unnatural pentaketide, 2,7-dihydroxy-5-methylchromone, from five molecules of malonyl-CoA, not a 5,7-diydroxy-5-methylchromne like the pentaketide chromone synthase, EC 2.3.1.216 722034
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25G207T site-directed mutagenesis, the G207T mutant loses the octaketide-forming activity and yields a hexaketide, 6-(2,4-dihydroxy-6-methylphenyl)-4-methoxy-2-pyrone, from six molecules of malonyl-CoA 722034
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25G207W site-directed mutagenesis, the mutant loses the octaketide-forming activity and yields a tetraketide, tetracetic acid lactone, along with the triketide, triacetic acid lactone, without the formation of an aromatic ring system 722034
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25more biosynthesis of the C-glucosylated anthraquinone, dcII, a precursor for carminic acid, using a combination of enzymes derived from Aloe arborescens, Streptomyces sp. R1128, and the insect Dactylopius coccus. The pathway, which consists of AaOKS, StZhuI, StZhuJ, and DcUGT2, presents an alternative biosynthetic approach for the production of polyketides by using a type III polyketide synthase (PKS) and tailoring enzymes originating from a type II PKS system. Transient expression in Nicotiana benthamiana. Method, detailed overview 756452
Results 1 - 10 of 14 > >>