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Results 1 - 9 of 9
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.42DHAPATDELTA135 the mutant enzyme is completely inactive 755947
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.42K852L mutant shows no activity and fails to support normal growth and survival during the stationary phase 720841
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.42more construction of a DELTAmdat/DELTAlmdat null mutant results in complete abrogation of the parasite dihydroxyacetone phosphate acyltransferase activity, lack of LmDAT causes a major alteration in parasite division during the logarithmic phase of growth, an accelerated cell death during stationary phase, and loss of virulence in mice, phenotype, overview 674766
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.42more deficient cell line caused by DNA 128 bp deletion leading to premature stop, strongly reduced activity 486971
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.42more deletion analyses show that the large N-terminal extension of this initial acyltransferase may be important for its stability or activity. Abrogation of the C-terminal glycosomal targeting signal sequence of LmDAT lead to extraglycosomal localization, do not impair its enzymatic activity but affect synthesis of the ether glycerolipid-based virulence factor lipophosphoglycan 720841
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.42more enzyme amount is reduced by 90% in Zellweger syndrome 486972
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.42more null mutant deltalmdat/deltalmdat, and complemented null mutant, double mutants with additional loss of glycerol-3-phosphate acyltransferase (LmGAT) are not viable, thus, these two may be the only acyltransferases -, 705601
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.42more null mutations of GAT1 andGAT2 are lethal 486391
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.42more patients affected with rhizomelic chondrodysplasia punctata show reduced enzyme activity due to a defect in peroxisomal targeting, point mutation at nucleotide 848 leading to a premature stop 486971
Results 1 - 9 of 9