EC Number |
Protein Variants |
Reference |
---|
2.3.1.129 | G189S |
Escherichia coli strain SM101 is deficient in LpxA activity due to a G189S inactivating mutation. Enzymatic activity is restored when the mutant strain is transformed with a wild-type bearing plasmid is inactive |
706784 |
2.3.1.129 | G52L/R58L |
residue tolerance in the beta-helical domain: mutation is tolerated |
706784 |
2.3.1.129 | G52V/R58V |
residue tolerance in the beta-helical domain: mutation is tolerated |
706784 |
2.3.1.129 | G52W/R58W |
residue tolerance in the beta-helical domain: mutation is tolerated |
706784 |
2.3.1.129 | G57P/N51P |
residue tolerance in the beta-helical domain: mutation is not tolerated |
706784 |
2.3.1.129 | H122A |
lower specific activity than wild-type |
486258 |
2.3.1.129 | H122N |
lower specific activity than wild-type |
486258 |
2.3.1.129 | H125A |
H125 is an important residue at the active site its mutation eliminates activity. Mutant shows significant growth reduction after introduction into Escherichia coli strain SM101 bearing a defective LpxA gene (G189S), and under novobiocin supplementation |
706784 |
2.3.1.129 | H125A |
lower specific activity than wild-type |
486258 |
2.3.1.129 | H125N |
lower specific activity than wild-type |
486258 |