EC Number   |
Protein Variants |
Reference |
|---|
   2.1.1.356 | A677G |
the mutant cell line reveals aberrantly elevated trimethylated [histone H3]-L-lysine27 and decreased monomethylated and dimethylated [histone H3]-L-lysine27 as compared to the wild type. The mutant enzyme demonstrates nearly equal efficiency for all three substrates (unmethylated H3K27:monomethylated H3K27:dimethylated H3K27 kcat/Km ratio is 1.1:0.6:1) |
755242 |
| 2.1.1.356 | C483A |
no activity, the SET domain cysteine 483 is a critical residue for the histone methyltransferase activity of RE-IIBP |
705683 |
| 2.1.1.356 | D329A |
the mutant shows strongly reduced activity compared to the wild type enzyme |
-, 755536 |
| 2.1.1.356 | DELTAL350 |
the mutant shows strongly reduced activity compared to the wild type enzyme |
-, 755536 |
| 2.1.1.356 | F52Y |
can only mono- and di- but not tri-methylate H38(K27) |
675387 |
| 2.1.1.356 | F679Y |
the mutant is tolerated with about 2fold reduction compared with wild type |
704437 |
| 2.1.1.356 | F679Y |
the mutant retains the capacity to produce trimethylated histone H3(K27) |
704437 |
| 2.1.1.356 | F681Y |
the mutation dramatically reduces PRC2 HMTase |
704437 |
| 2.1.1.356 | H326A |
the mutant shows strongly reduced activity compared to the wild type enzyme |
-, 755536 |
| 2.1.1.356 | L116A |
the mutant shows strongly increased activity compared to the wild type enzyme |
754369 |
