EC Number   |
Protein Variants |
Reference |
|---|
    2.1.1.355 | C1197A |
mutation of conserved residue within the SET domain, loss of catalytic activity |
760057 |
| 2.1.1.355 | D209A |
in solution experiments with the wild type histone H3 sequence, the mutant shows a 100fold reduced activity as compared to wild-type Dim-5 |
703174 |
| 2.1.1.355 | D209S |
in solution experiments with the wild type histone H3 sequence, the mutant shows a 100fold reduced activity as compared to wild-type Dim-5 |
703174 |
| 2.1.1.355 | deltaANK |
is inactive as a coactivator |
674770 |
| 2.1.1.355 | deltaSET |
lacks the enzymatic activity in vitro, synergistic coactivator function observed with glucocorticoid receptor interacting protein 1, coactivator-associated arginine methyltransferase 1 is reduced but not eliminated |
674770 |
| 2.1.1.355 | E227A |
in solution experiments with the wild type histone H3 sequence, the mutant shows a 10fold reduced activity as compared to wild-type Dim-5 |
703174 |
| 2.1.1.355 | E227S |
in solution experiments with the wild type histone H3 sequence, the mutant shows a 10fold reduced activity as compared to wild-type Dim-5 |
703174 |
| 2.1.1.355 | F281W |
shows catalytic activity |
671291 |
| 2.1.1.355 | F281Y |
shows catalytic activity |
671291 |
| 2.1.1.355 | F326A |
the mutant shows significantly reduced activity compared to the wild type enzyme |
753746 |
