EC Number |
Protein Variants |
Reference |
---|
2.1.1.354 | G951S |
the mutation displays benomyl resistance equivalent to that caused by enzyme deletion. The mutation affects Mad2 localization in dividing cells |
-, 753744 |
2.1.1.354 | more |
HMT activity of set1 null mutant strain is significantly reduced compared with the wild-type strain |
676066 |
2.1.1.354 | more |
set1 null mutant, heterozygous mutant, and reinsertion strains, HMT activity of the set1 null mutant strain is significantly reduced compared with strain CAI12, heterozygous mutant and reinsertion strains, disruption of SET1 results in complete loss of methylation of histone 3 at lysine residue 4, hyperfilamentous growth under embedded conditions, less negative cell surface charges and diminished adherence to epithelial cells, effects reversed upon gene reinsertion at a disrupted locus |
-, 676066 |
2.1.1.354 | more |
the removal of the WD40 domain-containing subunits Swd1 and Swd3 of the complex of proteins associated with Set1, which contribute to the stability of Set1, leads to a loss of Set1 protein and consequently a complete loss of histone H3(K4) methylation |
720034 |
2.1.1.354 | S289N |
the PRDM7 mutant loses the dimethylated substrate specificity and instead gains the ability to methylate H3K36 similar to, but less efficiently than its evolutionary predecessor PRDM9 |
754135 |
2.1.1.354 | S289N/S312W/S357Y |
the PRDM7 mutant regains the substrate specificities and catalytic activities similar to its evolutionary predecessor PRDM9, including the ability to efficiently methylate histone H3 lysine 36 |
754135 |
2.1.1.354 | S312W |
the PRDM7 mutant loses the dimethylated substrate specificity and instead gains the ability to methylate H3K36 similar to, but less efficiently than its evolutionary predecessor PRDM9 |
754135 |
2.1.1.354 | S357Y |
the PRDM7 mutant regains the substrate specificities and catalytic activities similar to its evolutionary predecessor PRDM9, including the ability to efficiently methylate histone H3 lysine 36 |
754135 |