EC Number   |
Protein Variants |
Reference |
|---|
   1.21.1.1 | A220T |
naturally occuring mutation involved in iodotyrosine deiodinase |
733237 |
| 1.21.1.1 | E153Q |
mutation reduces the deiodinase activity to an undetectable level. Mutant exhibits no measurable binding affinity for the substrate |
726449 |
| 1.21.1.1 | E153Q |
the mutant exhibits no measurable binding affinity for 3-chloro-L-tyrosine |
726449 |
| 1.21.1.1 | E154Q |
the mutation diminishes the affinity of the enzyme for 3,5-diiodo-L-tyrosine by 30fold |
746394 |
| 1.21.1.1 | G258D |
a naturally occuring sup-18 loss-of-function mutation |
734996 |
| 1.21.1.1 | G258S |
a naturally occuring sup-18 loss-of-function mutation |
734996 |
| 1.21.1.1 | G280R |
a naturally occuring sup-18 loss-of-function mutation |
734996 |
| 1.21.1.1 | I116T |
naturally occuring mutation involved in iodotyrosine deiodinase deficiency, the mutant shows highly reduced activity compared to te wild-type enzyme |
733237 |
| 1.21.1.1 | K178Q |
upon expression in Escherichia coli, inactive and insoluble |
726449 |
| 1.21.1.1 | K179Q |
the mutation diminishes the affinity of the enzyme for 3,5-diiodo-L-tyrosine by 46fold |
746394 |
