EC Number   |
Protein Variants |
Reference |
|---|
   1.2.4.2 | E952Q |
in this mutant the activation of thiamine diphosphate is impaired |
-, 763403 |
| 1.2.4.2 | H260A |
mutant has a dramatically reduced catalytic rate |
688353 |
| 1.2.4.2 | H298A |
mutant has a dramatically reduced catalytic rate |
688353 |
| 1.2.4.2 | H298D |
mutation in subunit E1o, active for 2-oxovalerate in an E1o-specific assay |
762591 |
| 1.2.4.2 | H298D |
the mutant enzyme shows 4.4fold increased activity toward 2-oxovalerate and 1200fold decreased activity toward 2-oxoglutarate compared to the wild type enzyme |
762591 |
| 1.2.4.2 | H348F |
mutation in subunit Eo, leads to activity for 2-oxovalerate in the reconstituted complex with E1o-H298D |
762591 |
| 1.2.4.2 | H348Q |
mutation in subunit Eo, leads to activity for 2-oxovalerate in the reconstituted complex with E1o-H298D |
762591 |
| 1.2.4.2 | H348Y |
mutation in subunit Eo, leads to activity for 2-oxovalerate in the reconstituted complex with E1o-H298D |
762591 |
| 1.2.4.2 | H352C |
the activity of the mutant is significantly reduced |
-, 719719 |
| 1.2.4.2 | H352C/Q356D |
the mutations fully prevent succinyltransferase activity |
-, 719719 |
