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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.18.B1more after transfecting the JMJD3 expression plasmid into normal CD4+ T cells isolated from healthy donors, upregulation of JMJD3 binding and the reduction of H3K27me3 enrichment within the CD11a promoter occurs, which increases CD11a expression and enhanced T cell auto-reactivity. In contrast, downregulation of JMJD3 by siRNA-mediated knockdown, reduces JMJD3 binding and increases H3K27me3 enrichment within the CD11a promoter, which suppresses CD11a expression and reverses the auto-reactivity of T cells in systemic lupus erythematosus patients 745948
Display the word mapDisplay the reaction diagram Show all sequences 1.14.18.B1more knockdown or knockout of PHF8 by RNAi or CRISPR-Cas9 system 744413
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