EC Number   |
Protein Variants |
Reference |
|---|
   1.14.14.83 | more |
co-overexpression of G10H with the 1-deoxy-D-xylulose synthase, DXS, from Arabidopsis thaliana causes a significant increase in ajmalicine by 16%, lochnericine by 31% and tabersonine by 13%. To increase the flux toward vinblastine and vincristine, a multiple genes within the pathway need to be overexpressed, terpenoid indole alkaloid profile, overview |
716102 |
| 1.14.14.83 | more |
construction of hairy root lines with inducible overexpression of 1-deoxy-D-xylulose synthase, DXS, or geraniol-10-hydroxylase, G10H |
716102 |
| 1.14.14.83 | more |
effect of differential T-DNA transfer on transcript accumulation of MIA biosynthetic pathway genes, expression of gene g10h is 15 to 130fold increased, overview |
716501 |
| 1.14.14.83 | more |
microsomes isolated from insect cells co-expressing Nothapodytes foetida NfCPR2 and Catharanthus roseus geraniol 10-hydroxylase show enhanced the production of eriodictyol from naringenin approximately 11fold relative to control G10H-only insect cells, indicating the supportive role of NfCPR2 for G10H activity in insect cells. Addition of FAD and FMN up to 0.01 mM does not increase the supportive function of the NfCPR2 for G10H activity |
718240 |
| 1.14.14.83 | more |
overexpression of individual geraniol 10-hydroxylase, G10H (G lines), significantly improves camptothecin (CPT) production with respect to non-transgenic hairy root cultures (NC line) and single strictosidine synthase (STR, EC 4.3.3.2) overexpressing lines (S lines), indicating that G10H plays a more important role in stimulating CPT accumulation than STR in Ophiorrhiza pumila. Co-overexpression of G10H and STR genes (SG Lines) causes a 56% increase on the yields of CPT compared to NC line and single gene transgenic lines, show that simultaneous introduction of G10H and STR can produce a synergistic effect on CPT biosynthesis in Ophiorrhiza pumila. camptothecin accumulates in the hairy roots. G10H is a key regulation target gene for metabolic engineering of CPT biosynthetic pathway |
746441 |
