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Results 1 - 7 of 7
EC Number Protein Variants Commentary Reference
Show all pathways known for 1.14.11.8Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.8D244E the Km-value of the variant enzyme for N6,N6,N6-trimethyl-L-lysine is 3.7fold lower than the Km-value of the wild-type enzyme, the Km-value of the variant enzyme for 2-oxoglutarate is 2.7fold higher than the Km-value of the wild-type enzyme 764104
Show all pathways known for 1.14.11.8Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.8H389L enzyme not functional 675029
Show all pathways known for 1.14.11.8Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.8more construction of senescence marker protein-30/gluconolactonase knockout mice, which cannot synthesize L-ascorbate in vivo, the mutant mice nevertheless produce normal levels of carnitine when fed an L-ascorbate lacking diet 691166
Show all pathways known for 1.14.11.8Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.8T269A the Thr269Ala variant displays high enzymatic activity (96% at 0.10 mM, 76% at 0.003 mM) for the conversion of (2S)-Nepsilon-trimethyllysine to (2S,3S)-3-hydroxy-Nepsilon-trimethyllysine 764104
Show all pathways known for 1.14.11.8Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.8W221F the variant displays considerably reduced enzymatic activity (32%), implying that the OH group of Tyr404 contributes to stronger interaction with the trimethylammonium group of (2S)-Nepsilon-trimethyllysine 764104
Show all pathways known for 1.14.11.8Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.8Y217D the variants does not display any enzymatic activity within limits of detection 764104
Show all pathways known for 1.14.11.8Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.8Y217E the Thr269Ala variant displays high enzymatic activity (96% at 0.10 mM, 76% at 0.003 mM) for the conversion of (2S)-Nepsilon-trimethyllysine to (2S,3S)-3-hydroxy-Ne-trimethyllysine 764104
Results 1 - 7 of 7