EC Number |
Protein Variants |
Reference |
---|
1.13.12.3 | C339A |
slight decrease in activity with tryptophan or methionine |
439346 |
1.13.12.3 | C511S |
high decrease in activity with tryptophan or methionine |
439346 |
1.13.12.3 | H338N |
slight decrease in activity with tryptophan or methionine |
439346 |
1.13.12.3 | K365M |
mutation decreases the kcat and kcat/Km (L-tryptophan) values by 60000- and 2 millionfold compared to wild-type, respectively |
727017 |
1.13.12.3 | R98A |
decrease in Vmax, increase in Km-value of tryptophan |
654682 |
1.13.12.3 | R98K |
decrease in Vmax, increase in Km-value of tryptophan |
654682 |
1.13.12.3 | W466F |
mutation decreases the kcat value less than 2fold and the kcat/Km (L-tryptophan) value only 5fold compared to wild-type |
727017 |
1.13.12.3 | W466M |
mutation results in an enzyme lacking flavin and detectable activity |
727017 |
1.13.12.3 | Y413A |
200fold reduction in first-order rate constant for reduction, 33fold decrease in rate constant for oxidation, conversion of enzyme to oxidase |
654683 |
1.13.12.3 | Y413F |
35fold reduction in first-order rate constant for reduction, 11fold decrease in rate constant for oxidation, conversion of enzyme to oxidase |
654683 |