EC Number |
Protein Variants |
Reference |
---|
1.1.1.35 | D279E |
naturally occuring polymorphism probably involved in development of type 2 diabetes |
673264 |
1.1.1.35 | D45G/Y214H |
a naturally occuring enzyme mutation causing human disease |
741307 |
1.1.1.35 | H138A |
the mutant shows a slightly lower Km value and a significantly lower kcat value than the wild type enzyme |
760296 |
1.1.1.35 | H152Q |
naturally occuring polymorphism probably involved in development of type 2 diabetes |
673264 |
1.1.1.35 | K50A |
site-directed mutagenesis, the mutant shows about 2fold increased activity compared to the wild-type enzyme |
740854 |
1.1.1.35 | K50A//L232Y |
site-directed mutagenesis, the mutant shows about 3fold increased activity compared to the wild-type enzyme |
740854 |
1.1.1.35 | K50A/K54 |
site-directed mutagenesis, the mutant shows about 3fold increased activity compared to the wild-type enzyme |
740854 |
1.1.1.35 | K50A/K54A/L232Y |
site-directed mutagenesis, the mutant shows about 5fold increased activity compared to the wild-type enzyme |
740854 |
1.1.1.35 | K54A |
site-directed mutagenesis, the mutant shows about 2fold increased activity compared to the wild-type enzyme |
740854 |
1.1.1.35 | K54A/L232Y |
site-directed mutagenesis, the mutant shows about 4fold increased activity compared to the wild-type enzyme |
740854 |