EC Number   |
Protein Variants |
Reference  |
|---|
    6.3.4.2 | D107A |
enzyme exhibits wild-type NH3-dependent activity and affinity for glutamine, but impaired glutamine-dependent CTP formation, affinity of the mutant enzyme for GTP is reduced 2-4fold |
648962 |
| 6.3.4.2 | E103A |
mutant enzyme exhibits no glutamine-dependent activity and is only partially active with NH3 |
648962 |
| 6.3.4.2 | G110A |
affinity of the mutant enzyme for GTP is reduced 2-4fold, enzyme exhibits wild-type NH3-dependent activity and affinity for glutamine, but impaired glutamine-dependent CTP formation |
648962 |
| 6.3.4.2 | H118A |
mutant enzyme exhibits no glutamine-dependent activity and is only partially active with NH3 |
648962 |
| 6.3.4.2 | K102A |
mutant enzyme exhibits wild-type activity with respect to NH3 and glutamine |
648962 |
| 6.3.4.2 | L109A |
enzyme exhibits wild-type NH3-dependent activity and affinity for glutamine, but impaired glutamine-dependent CTP formation, affinity of the mutant enzyme for GTP is reduced 2-4fold |
648962 |
| 6.3.4.2 | R104A |
mutant enzyme exhibits no glutamine-dependent activity and is only partially active with NH3 |
648962 |
| 6.3.4.2 | R105A |
enzyme exhibits wild-type NH3-dependent activity and affinity for glutamine, but impaired glutamine-dependent CTP formation |
648962 |
| 6.3.4.2 | C379A |
mutant enzyme is fully active with ammonia but has no glutamine-dependent activity, no inhibition by glutamate gamma-semialdehyde |
648963 |
| 6.3.4.2 | S330A |
CTP synthetase activity in cells bearing the mutant enzyme is elevated, mutation causes an elevation in the Vmax of the reaction. Mutation does not have a major effect on the oligomerization of CTP synthetase |
648973 |
