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Results 1 - 10 of 59 > >>
EC Number
Protein Variants
Commentary
Reference
A20R
mutation disrupts cytoophidium assembly
C379A
mutant enzyme is fully active with ammonia but has no glutamine-dependent activity, no inhibition by glutamate gamma-semialdehyde
C404G
inactive
D107A
enzyme exhibits wild-type NH3-dependent activity and affinity for glutamine, but impaired glutamine-dependent CTP formation, affinity of the mutant enzyme for GTP is reduced 2-4fold
D149E
the single point mutation in the resistant strain L2/CPEC results in loss of CTP feedback inhibition, cells are resistant to the cytotoxic effects of cyclopentenyl cytosine
D70A
mutation in the ATP binding site, mutant exhibits approximately twofold increase in the number of cells containing filaments
DELTA20
deletion of the N-terminal 20 amino acids alone is sufficient to disrupt cytoophidium assembly, mutant protein forms distinct cytoplasmic structures which appear as large clusters
E103A
mutant enzyme exhibits no glutamine-dependent activity and is only partially active with NH3
E146A
mutation in the ATP binding site, mutant exhibits approximately twofold increase in the number of cells containing filaments
E161K
mutation in CTP binding site, filament formation is completely disrupted and the enzyme can only form foci. Mutation decreases the affinity of the enzyme for CTP
Results 1 - 10 of 59 > >>