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Results 1 - 10 of 10
EC Number Protein Variants Commentary Reference
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6K443A at pH 8.0, 6.33 and 9.33 the mutant enzyme shows no measurable activity 721605
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6K443M at pH 8.0, 6.33 and 9.33 the mutant enzyme shows no measurable activity 721605
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6E380A kcat/Km is 74.3fold lower compared to wild-type value 721613
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6E380D retains a functional general base with a pKa of about 7.4 for kcat. The acidic region of the log (kcat/Km) versus pH profiles displays an ionizable group with a pKa of about 7.7. kcat/Km is 1.4fold lower compared to wild-type value 721613
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6E380Q variant displays a plateau in the acidic region. The acidic region of the log (kcat/Km) versus pH profiles becomes pH-independent for E380Q. kcat/Km is 3.8fold lower compared to wild-type value 721613
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6Y345A mutant exhibits a 5fold increase in Km of (2S,5S)-5-carboxymethylproline and a 165fold decrease in specificity constant compared to wild-type enzyme. kcat/Km is 165fold lower compared to wild-type value 721613
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6Y345A/E380A kcat/Km is 87fold lower compared to wild-type value 721613
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6Y345F pH-dependent kcat and kcat/Km plots retain the bell-shaped curve of wild-type CPS with similar pK values. kcat/Km is 1.7fold lower compared to wild-type value 721613
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6Y345F/E380D kcat/Km is 87fold lower compared to wild-type value 721613
Show all pathways known for 6.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.3.6Y345F/E380Q kcat/Km is 95fold lower compared to wild-type value 721613
Results 1 - 10 of 10