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EC Number
Protein Variants
Commentary
Reference
3.6.1.28
E63Q
reduced activity
667797
3.6.1.28
E78K
reduced activity
667797
3.6.1.28
E85K
reduced activity
667797
3.6.1.28
K85E
decreased solubility, reduced catalytic activity
667797
3.6.1.28
more
overexpression of N-myc downstream regulated gene-1, Ndrg-1, leads to upregulation of Thtpa in cancer cells, overview
696404
3.6.1.28
D147A
about 30% of wild-type catalytic efficiency
733393
3.6.1.28
D37A
about 0.5% of wild-type catalytic efficiency
733393
3.6.1.28
E81A
about 30% of wild-type catalytic efficiency
733393
3.6.1.28
K11A
about 15% of wild-type catalytic efficiency
733393
3.6.1.28
K193A
about 60% of wild-type catalytic efficiency
733393
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