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Results 1 - 10 of 28 > >>
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17P133F 3fold decrease in kcat value 733450
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17P133A 5fold increase in Km value 733450
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17T70A active site mutant, has no effect on platelet aggregation and secretion 733563
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17E58A crystallization data 733257
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17R54Q fusion protein containing and N-terminal extension Gly-Pro-Leu-Gly-Ser-Pro-Asn-Cys. Cleavage of (2'-pdA)AppppA to produce ATP and 2'-deoxyadenylated AMP rather than 2'-deoxyadenylated ATP + AMP as with wild-type enzyme, the ratio of ATP released is increased compared to wild-type. 330fold reduction in sensitivity to fluoride 654489
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17E59Q fusion protein containing and N-terminal extension Gly-Pro-Leu-Gly-Ser-Pro-Asn-Cys. KM-value is 2.4fold higher than the wild-type value, turnover-number is 0.00076% of the wild-type value. Activity with (2'-pdA)AppppA is to low to be detected 654489
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17E122Q fusion protein containing and N-terminal extension Gly-Pro-Leu-Gly-Ser-Pro-Asn-Cys. KM-value is 20% of the wild-type value, turnover-number is 50% of the wild-type value. 2.3fold reduction in sensitivity to fluoride 654489
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17E58D fusion protein containing and N-terminal extension Gly-Pro-Leu-Gly-Ser-Pro-Asn-Cys. KM-value is 38.4% of the wild-type value, turnover-number is 9% of the wild-type value. Cleavage of (2'-pdA)AppppA to produce ATP and 2'-deoxyadenylated AMP rather than 2'-deoxyadenylated ATP + AMP as with wild-type enzyme, the ratio of ATP released is increased compared to wild-type. 16.7fold reduction in sensitivity to fluoride 654489
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17E59D fusion protein containing and N-terminal extension Gly-Pro-Leu-Gly-Ser-Pro-Asn-Cys. KM-value is 4fold higher than the wild-type value, turnover-number is 0.02% of the wild-type value. Activity with (2'-pdA)AppppA is to low to be detected. 2fold reduction in sensitivity to fluoride 654489
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.17E58Q fusion protein containing and N-terminal extension Gly-Pro-Leu-Gly-Ser-Pro-Asn-Cys. KM-value is 80% of the wild-type value, turnover-number is 43.9% of the wild-type value. 6.7fold reduction in sensitivity to fluoride 654489
Results 1 - 10 of 28 > >>
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