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Results 1 - 8 of 8
EC Number
Amino acid exchange
Commentary
Reference
C104S
site-directed mutagenesis, the mutant is affected in its catalytic activity of proteolytic processing
C116S
site-directed mutagenesis, the mutant is affected in its catalytic activity of proteolytic processing
C122S
site-directed mutagenesis, the mutant is affected in its catalytic activity of proteolytic processing
C139A
cysteine residue responsible for hydrolysis
C139S
site-directed mutagenesis, the mutant is affected in its catalytic activity of proteolytic processing
E54A
Glu at the active centre
E54L
the E54L mutant protease is a substrate-specificity mutant and requires large hydrophobic amino acid residues at both P4 and P2 positions of the substrate, it cleaves the sequence 133LSFE/AP between the 3B and 3C regions of norovirus polyprotein, but does not cleaves the sequence 198ATSE/GK between the 3A and 3B
more
acidic amino acid (Glu or Asp), as well as the His and Cys in the putative catalytic triad, cannot be replaced by Ala for normal processing activity of the ORF1 polyprotein in vitro. Similarly, normal activity is not retained if the nucleophile Cys is replaced with Ser
Results 1 - 8 of 8