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Results 1 - 10 of 23 > >>
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55K152A mutant enzyme with strikingly altered caspase-2 localization. Whereas caspase-2 characteristically accumulates in the nucleus forming dots or filaments, the mutant enzyme is mostly localized outside and exclusively of the nucleus forming dot-like aggregates. K152A mutants can also kill transfected cells at comparable levels to the wild-type version 647762
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55more caspase prodomain-DELTA25 mutant is slightly less effective than wild-type caspase-2, inducing cell death of about 70% of transfected cells. Caspase prodomain-DELTA25 mutant cannot kill due to its impaired nuclear localization 647762
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55C320A forms a dimer only when cell are treated with DRB 664753
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55S157A/C320A nonphosphorylatable, dimerizes constitutively 664753
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55C303A inactive 664882
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55D152A pro-caspase mutant, like the wild-type, this mutant is efficiently processed between the large and the small subunit, however, it is not further processed to seperate the prodomain from the large subunit 664882
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55D316A fusion of the linker to the large subunit, toxic when expressed in yeast 664882
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55D316A/D330A abolishes auto-processing and reduces enzymatic activity dramatically, 840fold decrease in activity 664882
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55D330A fusion of the linker to the small subunit, slightly greater deleterious effect on enzyme activity than fusion to the large subunit (D316A), toxic when expressed in yeast 664882
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.55C303A catalytically inactive 665588
Results 1 - 10 of 23 > >>