EC Number |
Protein Variants |
Reference |
---|
3.4.22.55 | D316A/D330A |
abolishes auto-processing and reduces enzymatic activity dramatically, 840fold decrease in activity |
664882 |
3.4.22.55 | more |
caspase prodomain-DELTA25 mutant is slightly less effective than wild-type caspase-2, inducing cell death of about 70% of transfected cells. Caspase prodomain-DELTA25 mutant cannot kill due to its impaired nuclear localization |
647762 |
3.4.22.55 | C320A |
catalytic residue, inactive mutant enzyme |
713154 |
3.4.22.55 | C303A |
catalytically inactive |
665588 |
3.4.22.55 | C320A |
catalytically inactive |
732048 |
3.4.22.55 | S139An |
expression of mutant S139A leads to significantly enhanced growth rate of cells |
732048 |
3.4.22.55 | C320A |
forms a dimer only when cell are treated with DRB |
664753 |
3.4.22.55 | D316A |
fusion of the linker to the large subunit, toxic when expressed in yeast |
664882 |
3.4.22.55 | D330A |
fusion of the linker to the small subunit, slightly greater deleterious effect on enzyme activity than fusion to the large subunit (D316A), toxic when expressed in yeast |
664882 |
3.4.22.55 | C303A |
inactive |
664882 |