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Results 1 - 10 of 23 > >>
EC Number
Amino acid exchange
Commentary
Reference
D316A/D330A
abolishes auto-processing and reduces enzymatic activity dramatically, 840fold decrease in activity
more
caspase prodomain-DELTA25 mutant is slightly less effective than wild-type caspase-2, inducing cell death of about 70% of transfected cells. Caspase prodomain-DELTA25 mutant cannot kill due to its impaired nuclear localization
C320A
catalytic residue, inactive mutant enzyme
C303A
catalytically inactive
C320A
catalytically inactive
S139An
expression of mutant S139A leads to significantly enhanced growth rate of cells
C320A
forms a dimer only when cell are treated with DRB
D316A
fusion of the linker to the large subunit, toxic when expressed in yeast
D330A
fusion of the linker to the small subunit, slightly greater deleterious effect on enzyme activity than fusion to the large subunit (D316A), toxic when expressed in yeast
C303A
inactive
Results 1 - 10 of 23 > >>