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Results 1 - 10 of 31 > >>
EC Number
Amino acid exchange
Commentary
Reference
C1129S
inactive
C2029A
-
C2029A
no autoproteolytic cleavage, unable to cleave SCC1
E1483R/R1486E
autoproteolytically cleaved like wild-type
E1503R/R1506E
autoproteolytically cleaved like wild-type
E1532R/R1535E
autoproteolytically cleaved like wild-type
H1531A
active site point mutation prevents Scc1 from being cleaved after binding
more
analysis of the homozygous zebrafish mutant cds (cease&desist), bearing a mutation in the separase gene, reveals high levels of polyploidy and aneuploidy, spindle defects, and a mitotic exit delay in mutant embryos. Carcinogenesis studies demonstrate that cds heterozygous adults have an eightfold increase in the percentage of fish bearing epithelial tumors
more
clear evidence for a non-proteolytic function of separase is provided: by separase gene deletion in mouse oocytes it is shown that separase null-oocytes are unable to either destroy chesin along chromosome arms or segregate homologous chromosomes and these oocytes are unable to complete cell division. Microinjection of wild-type separase mRNA in separase null-oocytes restores normal homologue disjunction and polar body extrusion
more
generation of human cells with one hESP allele-encoding uncleavable protein and another allele harboring a single cleavage site, the cells grow slowly owing to cell cycle delay, in particular during G2/M transition, but not when it was expected, i.e. during anaphase
Results 1 - 10 of 31 > >>