EC Number   |
Protein Variants |
Reference  |
|---|
   3.4.18.1 | D253K |
reversed polarity and improved activity |
36392 |
| 3.4.18.1 | D253R |
reversed polarity and improved activity |
36392 |
| 3.4.18.1 | G251T/D253K |
double mutant, improved activity |
36392 |
| 3.4.18.1 | more |
- |
36392 |
| 3.4.18.1 | more |
cell surface cathepsin X compensates for CTSB in PyMT,ctsb-/- tumor cells, overview |
679023 |
| 3.4.18.1 | more |
the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis, SOD1-G93A, and associated with plaques in transgenic mice expressing the human amyloid precursor protein APP containing the mutation K670M/N671L, overview |
683448 |
| 3.4.18.1 | more |
cathepsin X overexpression reduces LFA-1 clustering and induces an intermediate affinity LFA-1 conformation that is known to associate with alpha-actinin-1. Migration of primary T cell is reduced by cathepsin X-specific siRNA silencing |
708379 |
| 3.4.18.1 | more |
generation of Ctsz null mice and crossing with Ctsb-deficient mice harboring a transgene for the mammary duct-specific expression of polyoma middle T oncogene, PymT. The double mutant mice show significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading, as well as a 70% reduction in the number of lung metastases and an 80% reduction in the size of these metastases. The double deficiency of Ctsb and Ctsz exerts significant synergistic anticancer effects, whereas the single deficiencies demonstrate at least partial reciprocal compensation |
710431 |
