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Results 1 - 8 of 8
EC Number
Amino acid exchange
Commentary
Reference
D253K
reversed polarity and improved activity
D253R
reversed polarity and improved activity
G251T/D253K
double mutant, improved activity
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cathepsin X overexpression reduces LFA-1 clustering and induces an intermediate affinity LFA-1 conformation that is known to associate with alpha-actinin-1. Migration of primary T cell is reduced by cathepsin X-specific siRNA silencing
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cell surface cathepsin X compensates for CTSB in PyMT,ctsb-/- tumor cells, overview
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generation of Ctsz null mice and crossing with Ctsb-deficient mice harboring a transgene for the mammary duct-specific expression of polyoma middle T oncogene, PymT. The double mutant mice show significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading, as well as a 70% reduction in the number of lung metastases and an 80% reduction in the size of these metastases. The double deficiency of Ctsb and Ctsz exerts significant synergistic anticancer effects, whereas the single deficiencies demonstrate at least partial reciprocal compensation
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the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis, SOD1-G93A, and associated with plaques in transgenic mice expressing the human amyloid precursor protein APP containing the mutation K670M/N671L, overview
Results 1 - 8 of 8