EC Number   |
Protein Variants |
Reference |
|---|
   3.2.2.6 | more |
construction of CD38/NAD+ glycohydrolase truncated for the first 31 amino acids that encompass the transmembrane and short intracellular domains |
732691 |
| 3.2.2.6 | E226D |
site-directed mutagenesis, catalytic mutant |
731119 |
| 3.2.2.6 | E226Q |
site-directed mutagenesis, catalytic mutant |
731119 |
| 3.2.2.6 | E218Q |
site-directed mutagenesis, catalytic site mutant, crystal structure analysis, almost inactive mutant |
732691 |
| 3.2.2.6 | E138Q |
site-directed mutagenesis, in the presence of methanol, mutant E138Q efficiently catalyzes the formation of beta-1'-O-methyl ADP-ribose. But in contrast with mutant E138A, and like the wild-type enzyme, solvolysis does not affect the overall turnover rate of NAD+ indicating that the formation of the E.ADP-ribosyl intermediate is still rate limiting |
731357 |
| 3.2.2.6 | E226D |
site-directed mutagenesis, inactive catalytic site mutant |
731987 |
| 3.2.2.6 | E226Q |
site-directed mutagenesis, inactive catalytic site mutant |
731987 |
| 3.2.2.6 | N100D |
site-directed mutagenesis, N-glycoylation at the site is abolished |
731119 |
| 3.2.2.6 | N164D |
site-directed mutagenesis, N-glycoylation at the site is abolished |
731119 |
| 3.2.2.6 | N209D |
site-directed mutagenesis, N-glycoylation at the site is abolished |
731119 |
