EC Number   |
Protein Variants |
Reference |
|---|
   2.1.1.137 | M287T |
a naturally occurring T/C polymorphism in AS3MT among Japanese, Koreans, Chinese, Mongolians, Uygurs, Tibetans, Tamangs, Tamils, Sinhalese, Turks, Ovambos, Ghanaians, and Xhosas. Xhosas have the highest 287T frequency |
700331 |
| 2.1.1.137 | C11S |
activity similar to wild-type |
757684 |
| 2.1.1.137 | C193S |
activity similar to wild-type |
757684 |
| 2.1.1.137 | C268S |
activity similar to wild-type |
757684 |
| 2.1.1.137 | C10S |
activtiy similar to wild-type |
757684 |
| 2.1.1.137 | more |
an exon-4 and -5 skipping (DELTA4,5) truncated mutant form does not convert arsenite to monomethylarsonate or dimethylarsinic acid |
718748 |
| 2.1.1.137 | M287T |
genotype distribution and allele frequencies of M287T in Ovambo, Turkish, Mongolian, Korean, and Japanese populations , the mutation frequencies in Asian populations are relatively lower than those of African and Caucasian populations, the frequencies of mutation in the Mongolian, Korean, and Japanese populations, overview |
701300 |
| 2.1.1.137 | M287T |
in the absence of glutathione, the mutant shows decreased Vmax and Km for arsenite and increased Vmax and Km for methylarsonate compared to the wild type enzyme |
721075 |
| 2.1.1.137 | C165S |
inactive |
721074 |
| 2.1.1.137 | C210S |
inactive |
721074 |
