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Results 1 - 7 of 7
EC Number
Amino acid exchange
Commentary
Reference
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enzyme from strain ST-095 only differs in residue V366 from strain JC-12 (S366). Mutation results in almost 3fold higher catalytic efficiency in strain JC-12
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targeted disruption of the MSMEG5898 (ksdD-1) gene, but not the MSMEG4855 (ksdD-2) gene, results in partial inactivation of the cholesterol degradation pathway and accumulation of the intermediate 4-androstene-3,17-dione, reversible by the introduction of the wild-type ksdD-1 gene into deltaksdD-1 or overexpression of ksdD-2
S325F
mutant enzyme has no detectable KSTD enzyme activity
T503I
mutant enzyme has no detectable KSTD enzyme activity
Y119F
almost complete loss of activity
Y318F
almost complete loss of activity
Y487F
almost complete loss of activity
Results 1 - 7 of 7