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Results 1 - 6 of 6
EC Number
Amino acid exchange
Commentary
Reference
E142A
complete loss of enzymatic activity in vivo and in vitro, 2.1% of the active site iron as compared to wild-type enzyme, no self-hydroxylation at Tyr105
H138A
inactive in vivo, but in vitro it retains 27% of the active site iron and nearly 20% of the wild-type activity, limited self-hydroxylation (at Tyr105)
H180A
complete loss of enzymatic activity in vivo and in vitro, 5.8% of the active site iron as compared to wild-type enzyme, no self-hydroxylation at Tyr105
Y102F
mutant maintains 60% of the activity of the wild-type enzyme
Y103F
mutant maintains 60% of the activity of the wild-type enzyme
Y105F
mutant enzyme is inactive
Results 1 - 6 of 6