EC Number   |
Protein Variants |
Reference |
|---|
    6.3.4.2 | S571I/S574A/S575A |
phosphorylation by glycogen synthase kinase 3 shows a slight decrease in the amount of phosphate incorporated into CTPS1 compared with S571I/S575A, suggesting that Ser-574 may serve as a minor secondary site for glycogen synthase kinase 3 phosphorylation |
674862 |
| 6.3.4.2 | S571I/S575A |
phosphorylation by glycogen synthase kinase 3 shows slightly elevated amounts of phosphate incorporated into CTPS1 compared with S571I, suggesting that without the ability to phosphorylate Ser-571 or Ser-575 in vitro, glycogen synthase kinase 3 may phosphorylate an alternative site, albeit to a much lesser extent |
674862 |
| 6.3.4.2 | S574A |
greatly reduces phosphorylation by glycogen synthase kinase 3 |
674862 |
| 6.3.4.2 | S574A/S575A |
greatly reduces phosphorylation by glycogen synthase kinase 3 |
674862 |
| 6.3.4.2 | S575A |
greatly reduces phosphorylation by glycogen synthase kinase 3. Mutation of Ser-575 prevents the phosphorylation of Ser-571, suggesting that phosphorylation of Ser-575 is necessary for priming the glycogen synthase kinase 3 phosphorylation of Ser-571 |
674862 |
| 6.3.4.2 | S575A |
site-directed mutagenesis the mutant does not interact with peptidyl prolyl isomerase Pin1 |
694484 |
| 6.3.4.2 | T455A |
T455A mutation causes a 78% decrease in protein kinase A phosphorylation |
674886 |
| 6.3.4.2 | V349S |
mutation increases lability of the enzyme |
648980 |
| 6.3.4.2 | Y3E |
mutation disrupts cytoophidium assembly |
744847 |
