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<< < Results 11 - 17 of 17
EC Number Protein Variants Commentary Reference
Show all pathways known for 4.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 4.3.1.2F170A kcat (mesaconate) decreased compared to wild-type, Km (mesaconate) increased compared to wild-type. Conversion 2h: 63% (73% wild-type), diastereomeric product ratio (threo:erythro) after 2h: 95:5 (89:11 wild-type) 729745
Show all pathways known for 4.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 4.3.1.2T360S kcat (mesaconate) decreased compared to wild-type, Km (mesaconate) increased compared to wild-type. Conversion 2h: 76% (73% wild-type), diastereomeric product ratio (threo:erythro) after 2h: 86:14 (89:11 wild-type) 729745
Show all pathways known for 4.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 4.3.1.2L384A mutant displays pronounced amination activity towards 2-hexylfumarate ad decreased amination activity towards mesaconate compared to wild-type. Mutant displays a broad electrophile scope including fumarate derivatives with alkyl, aryl, alkoxy, aryloxy, alkylthio and arylthio substituents at the C2 position 730442
Show all pathways known for 4.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 4.3.1.2Q73A mutant displays significant decrease in ammonia addition and a large increase in methylamine addition compared to wild-type. Mutant displays a wide nucleophile scope including structurally diverse linear and cyclic allkylamines 730442
Show all pathways known for 4.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 4.3.1.2C361K mutant shows no reactivity. Conversion 2h: 10% (73% wild-type), diastereomeric product ratio (threo:erythro) after 2h: 95:5 (89:11 wild-type) 729745
Show all pathways known for 4.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 4.3.1.2Q172N mutant shows no reactivity. Conversion 2h: 6% (73% wild-type), diastereomeric product ratio (threo:erythro) after 2h: 95:5 (89:11 wild-type) 729745
Show all pathways known for 4.3.1.2Display the word mapDisplay the reaction diagram Show all sequences 4.3.1.2Q73N mutant shows very low-level amination activity preventing the measurement of kinetic parameters. Conversion 2h: 18% (73% wild-type), diastereomeric product ratio (threo:erythro) after 2h: 95:5 (89:11 wild-type) 729745
<< < Results 11 - 17 of 17