EC Number   |
Protein Variants |
Reference |
|---|
   3.4.22.55 | more |
knockdown of caspase-2 and overexpression of a caspase-2 mutant |
717457 |
| 3.4.22.55 | K152A |
mutant enzyme with strikingly altered caspase-2 localization. Whereas caspase-2 characteristically accumulates in the nucleus forming dots or filaments, the mutant enzyme is mostly localized outside and exclusively of the nucleus forming dot-like aggregates. K152A mutants can also kill transfected cells at comparable levels to the wild-type version |
647762 |
| 3.4.22.55 | S157A/C320A |
nonphosphorylatable, dimerizes constitutively |
664753 |
| 3.4.22.55 | S135A |
phosphorylation site |
711848 |
| 3.4.22.55 | S340A |
phosphorylation site, expression of mutant S340A more than doubles the sensitivity of cells to nocodazole-induced mitotic death compared with wild-type protein |
711848 |
| 3.4.22.55 | S308A |
phosphorylation site, S308 phosphorylated in mitosis, abrogates mitotic suppression, processing of mutant S308A in mitosis does not occur immediately, but rather occurs with roughly the same kinetics as wild-type caspase-2 in interphase |
711848 |
| 3.4.22.55 | S135A |
phosphorylation site, suppressed equally compared with wild type protein during mitosis |
711848 |
| 3.4.22.55 | D152A |
pro-caspase mutant, like the wild-type, this mutant is efficiently processed between the large and the small subunit, however, it is not further processed to seperate the prodomain from the large subunit |
664882 |
| 3.4.22.55 | S135A/S308A |
rapidly processed in mitosis compared with caspase-2 S308A mutant |
711848 |
| 3.4.22.55 | T380A |
site-directed mutagenesis |
717846 |
