EC Number   |
Protein Variants |
Reference |
|---|
   2.1.1.137 | M287T |
in the absence of glutathione, the mutant shows decreased Vmax and Km for arsenite and increased Vmax and Km for methylarsonate compared to the wild type enzyme |
721075 |
| 2.1.1.137 | M287T |
naturally occuring mutant |
697642 |
| 2.1.1.137 | M287T |
the mutation is associated with an increased percentage of monomethylated arsenic in urine |
718712 |
| 2.1.1.137 | M287T |
the substitution results in an increase in the capacity of the first step of methylation, leading to an increase in the percentage of urinary methylarsonate, but not the second step of methylation |
733451 |
| 2.1.1.137 | more |
an exon-4 and -5 skipping (DELTA4,5) truncated mutant form does not convert arsenite to monomethylarsonate or dimethylarsinic acid |
718748 |
| 2.1.1.137 | N155A |
inactive |
733425 |
| 2.1.1.137 | R57A |
the mutant's activity is seriously impaired compared with that of wild type |
733425 |
| 2.1.1.137 | R83A |
the mutants activity is seriously impaired compared with that of wild type |
733425 |
| 2.1.1.137 | S81A |
the mutants activity is seriously impaired compared with that of wild type |
733425 |
| 2.1.1.137 | T104A |
the mutants activity is seriously impaired compared with that of wild type |
733425 |
