EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    6.3.2.17 | Acute Coronary Syndrome |
25809277 |
Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
1
3
1
0 |
| 6.3.2.17 | Alzheimer Disease |
21383495 |
The MTHFD1L Gene rs11754661 Marker is Not Associated with Alzheimer's Disease in a Sample of the Spanish Population. |
causal interaction
diagnostic usage
unassigned |
4
4
0 |
| 6.3.2.17 | Alzheimer Disease |
21741665 |
The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population. |
diagnostic usage
ongoing research
unassigned |
3
2
0 |
| 6.3.2.17 | Alzheimer Disease |
22330827 |
Replication of the MTHFD1L Gene Association with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population. |
causal interaction
unassigned |
3
0 |
| 6.3.2.17 | Arthritis, Rheumatoid |
12673886 |
Expression of folylpolyglutamyl synthetase predicts poor response to methotrexate therapy in patients with rheumatoid arthritis. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
3
3 |
| 6.3.2.17 | Arthritis, Rheumatoid |
27752107 |
Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis. |
causal interaction
unassigned |
4
0 |
| 6.3.2.17 | Arthritis, Rheumatoid |
31008996 |
Development and validation of a sensitive UHPLC-MS/MS-based method for the analysis of folylpolyglutamate synthetase enzymatic activity in peripheral blood mononuclear cells: application in rheumatoid arthritis and leukemia patients. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
2
3
4 |
| 6.3.2.17 | Arthritis, Rheumatoid |
32940699 |
Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis. |
causal interaction
unassigned |
4
0 |
| 6.3.2.17 | Breast Neoplasms |
18499665 |
The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis. |
unassigned |
0 |
| 6.3.2.17 | Breast Neoplasms |
18804693 |
Chapter 4 molecular mechanisms of adaptation to folate deficiency. |
causal interaction
therapeutic application
unassigned |
2
1
0 |
