EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   6.2.1.15 | Adenocarcinoma |
11731423 |
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
2
4 |
| 6.2.1.15 | Adenocarcinoma of Lung |
34053456 |
High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma. |
causal interaction
diagnostic usage
unassigned |
1
3
0 |
| 6.2.1.15 | Adenoma |
11731423 |
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
2
4 |
| 6.2.1.15 | arachidonate-coa ligase deficiency |
30721098 |
Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet. |
ongoing research
unassigned |
4
0 |
| 6.2.1.15 | arachidonate-coa ligase deficiency |
31376475 |
Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages. |
causal interaction
unassigned |
3
0 |
| 6.2.1.15 | arachidonate-coa ligase deficiency |
31504388 |
Tissue Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis. |
causal interaction
unassigned |
3
0 |
| 6.2.1.15 | Atherosclerosis |
17259370 |
Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages. |
causal interaction
ongoing research
unassigned |
1
4
0 |
| 6.2.1.15 | Atherosclerosis |
33974977 |
Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
2
2
1 |
| 6.2.1.15 | Brain Edema |
33314758 |
Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 6.2.1.15 | Brain Infarction |
33889074 |
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
4
0 |
