EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    6.1.1.5 | Aortic Aneurysm, Abdominal |
30905780 |
Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways. |
ongoing research
unassigned |
4
0 |
| 6.1.1.5 | Aphasia |
30041933 |
Novel IARS2 mutations in Japanese siblings with CAGSSS, Leigh, and West syndrome. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 6.1.1.5 | Bacterial Infections |
25069899 |
Enzymatic glycosylation of the topical antibiotic mupirocin. |
causal interaction
therapeutic application
unassigned |
2
2
0 |
| 6.1.1.5 | Bone Resorption |
16537392 |
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. |
therapeutic application
unassigned |
1
0 |
| 6.1.1.5 | Candidiasis |
15388459 |
Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans. |
therapeutic application
unassigned |
4
0 |
| 6.1.1.5 | Candidiasis |
15855534 |
Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits. |
therapeutic application
unassigned |
4
0 |
| 6.1.1.5 | Carcinogenesis |
31157169 |
The Oncogene IARS2 Promotes Non-small Cell Lung Cancer Tumorigenesis by Activating the AKT/MTOR Pathway. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
2
4
4 |
| 6.1.1.5 | Carcinoma, Non-Small-Cell Lung |
26639235 |
IARS2 silencing induces non-small cell lung cancer cells proliferation inhibition, cell cycle arrest and promotes cell apoptosis. |
causal interaction
ongoing research
unassigned |
3
3
0 |
| 6.1.1.5 | Carcinoma, Non-Small-Cell Lung |
31157169 |
The Oncogene IARS2 Promotes Non-small Cell Lung Cancer Tumorigenesis by Activating the AKT/MTOR Pathway. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
2
4
4 |
| 6.1.1.5 | Cardiomyopathy, Hypertrophic |
21945886 |
Isoleucyl-tRNA synthetase levels modulate the penetrance of a homoplasmic m.4277T>C mitochondrial tRNA(Ile) mutation causing hypertrophic cardiomyopathy. |
unassigned |
0 |
