EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
6.1.1.4 | Acidosis, Lactic |
20194621 |
Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes. |
causal interaction unassigned |
2 0 |
6.1.1.4 | Acidosis, Lactic |
26537577 |
LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. |
causal interaction unassigned |
2 0 |
6.1.1.4 | Acidosis, Lactic |
28847973 |
Correction for Li and Guan, "Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNA(Leu(UUR)) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes". |
causal interaction unassigned |
1 0 |
6.1.1.4 | Acidosis, Lactic |
32442335 |
The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. |
causal interaction ongoing research therapeutic application unassigned |
3 1 1 0 |
6.1.1.4 | Anemia |
33300650 |
Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations. |
causal interaction therapeutic application unassigned |
4 1 0 |
6.1.1.4 | Anemia, Sideroblastic |
26537577 |
LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. |
causal interaction unassigned |
2 0 |
6.1.1.4 | Anemia, Sideroblastic |
32442335 |
The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. |
causal interaction ongoing research therapeutic application unassigned |
3 1 1 0 |
6.1.1.4 | Carcinogenesis |
18446061 |
Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 4 2 2 |
6.1.1.4 | Carcinogenesis |
19129950 |
Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. |
causal interaction diagnostic usage ongoing research unassigned |
4 4 1 0 |
6.1.1.4 | Carcinoma, Non-Small-Cell Lung |
31205503 |
Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer. |
ongoing research therapeutic application unassigned |
3 4 0 |