EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    6.1.1.2 | Acidosis, Lactic |
31282308 |
Expanding the Phenotype: Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements and Lactic Acidosis, With or Without Seizures (NEMMLAS) due to WARS2 Biallelic Variants, Encoding Mitochondrial Tryptophanyl-tRNA Synthase. |
causal interaction
unassigned |
4
0 |
| 6.1.1.2 | Acidosis, Lactic |
31684799 |
Expanding the Phenotype: Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements and Lactic Acidosis, With or Without Seizures (NEMMLAS) Due to WARS2 Biallelic Variants, Encoding Mitochondrial Tryptophanyl-tRNA Synthase. |
causal interaction
unassigned |
2
0 |
| 6.1.1.2 | Alzheimer Disease |
16616781 |
Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease. |
diagnostic usage
ongoing research
unassigned |
3
3
0 |
| 6.1.1.2 | Alzheimer Disease |
29973830 |
Synthetic Peptide Corresponding to The Amino-Terminal Region of the Human Tryptophanyl-Trna Synthetase, a Component Of Alzheimer'S Disease Special Congophlic Plaques Aggregates In Vitro to Form Amyloid-Like Fibrils. |
ongoing research
unassigned |
2
0 |
| 6.1.1.2 | Ataxia |
31282308 |
Expanding the Phenotype: Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements and Lactic Acidosis, With or Without Seizures (NEMMLAS) due to WARS2 Biallelic Variants, Encoding Mitochondrial Tryptophanyl-tRNA Synthase. |
causal interaction
unassigned |
4
0 |
| 6.1.1.2 | Athetosis |
28650581 |
Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy. |
causal interaction
unassigned |
4
0 |
| 6.1.1.2 | Brain Diseases |
28905505 |
Biallelic variants in WARS2 encoding mitochondrial tryptophanyl-tRNA synthase in six individuals with mitochondrial encephalopathy. |
causal interaction
unassigned |
3
0 |
| 6.1.1.2 | Breast Neoplasms |
24098497 |
Concurrent Gene Signatures for Han Chinese Breast Cancers. |
diagnostic usage
ongoing research
unassigned |
1
1
0 |
| 6.1.1.2 | Breast Neoplasms |
33408886 |
Tryptophanyl-tRNA Synthetase Sensitizes Hormone Receptor-Positive Breast Cancer to Docetaxel-Based Chemotherapy. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
1
4
3
0 |
| 6.1.1.2 | Carcinogenesis |
10376788 |
Tryptamine-mediated stabilization of tryptophanyl-tRNA synthetase in human cervical carcinoma cell line. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
2
1
4
3 |
