EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
  4.3.2.7 | Atherosclerosis |
25931127 |
Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element. |
causal interaction
therapeutic application
unassigned |
1
3
0 |
| 4.3.2.7 | Breast Neoplasms |
29091014 |
Development of a novel prognostic score for breast cancer patients using mRNA expression of CHAC1. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
4
2
3 |
| 4.3.2.7 | Breast Neoplasms |
29383104 |
CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2?-ATF4 pathway. |
ongoing research
unassigned |
2
0 |
| 4.3.2.7 | Breast Neoplasms |
31878259 |
Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism. |
causal interaction
unassigned |
3
0 |
| 4.3.2.7 | Carcinogenesis |
23342279 |
Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 4.3.2.7 | Carcinogenesis |
28686580 |
Upregulation of LYAR induces neuroblastoma cell proliferation and survival. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 4.3.2.7 | Carcinoma |
33728749 |
Ferroptosis-related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinoma. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
4
3
0 |
| 4.3.2.7 | Cardiovascular Diseases |
31756991 |
Source of Dietary Fat in Pig Diet Affects Adipose Expression of Genes Related to Cancer, Cardiovascular, and Neurodegenerative Diseases. |
unassigned |
0 |
| 4.3.2.7 | Colorectal Neoplasms |
28837156 |
CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
2
3 |
| 4.3.2.7 | Cystic Fibrosis |
30555487 |
CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by Pseudomonas aeruginosa. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
3
2
0 |
