EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.6.4.B10 | Adenocarcinoma of Lung |
31400757 |
Targeting ?-tubulin/CCT-? complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma. |
diagnostic usage
ongoing research
unassigned |
3
3
0 |
| 3.6.4.B10 | Alzheimer Disease |
25080104 |
The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in A?-expressing Caenorhabditis elegans. |
causal interaction
unassigned |
2
0 |
| 3.6.4.B10 | Anthrax |
23716698 |
CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. |
ongoing research
unassigned |
3
0 |
| 3.6.4.B10 | Astrocytoma |
11857388 |
Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas. |
causal interaction
diagnostic usage
unassigned |
1
2
0 |
| 3.6.4.B10 | Autoimmune Diseases |
27489109 |
Chaperonin-containing T-complex Protein 1 Subunit ? Serves as an Autoantigen Recognized by Human V?2 ?? T Cells in Autoimmune Diseases. |
diagnostic usage
unassigned |
3
0 |
| 3.6.4.B10 | Bardet-Biedl Syndrome |
15731008 |
MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis. |
therapeutic application
unassigned |
1
0 |
| 3.6.4.B10 | Blindness |
29450543 |
Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis. |
causal interaction
unassigned |
2
0 |
| 3.6.4.B10 | Breast Neoplasms |
25704758 |
Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes. |
causal interaction
diagnostic usage
unassigned |
3
3
0 |
| 3.6.4.B10 | Breast Neoplasms |
33815471 |
Systematic Characterization of Expression Profiles and Prognostic Values of the Eight Subunits of the Chaperonin TRiC in Breast Cancer. |
causal interaction
diagnostic usage
ongoing research
unassigned |
2
3
4
0 |
| 3.6.4.B10 | Carcinogenesis |
16401634 |
Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori. |
causal interaction
unassigned |
3
0 |
